SCHEMBL120037

SCHEMBL120037

CC(C)OC(=O)N1CCC([C@H](C)CCOc2cnc(N3C[C@H](c4ccccc4F)[C@@H](N)C3)nc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.43
BRD4 O60885 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL122288 0.95 GPR119 (0.43) GPR119BRD4
SCHEMBL149202 0.92 GPR119 (0.41) GPR119
SCHEMBL120013 0.91 GPR119 (0.42) GPR119
SCHEMBL121276 0.91 MCHR1 (0.43) GPR119
SCHEMBL121147 0.91 GPR119 (0.42) GPR119
SCHEMBL121320 0.90 DPP4 (0.44) GPR119
Hydrochloric Acid SCHEMBL148501 0.89 DPP4 (0.43) GPR119
SCHEMBL170490 0.86 GPR119 (0.42) GPR119
SCHEMBL122254 0.86 GPR119 (0.42) GPR119
SCHEMBL121161 0.85 DPP4 (0.39) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120059014-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-03-08 US disclosed
US-20120059014-A1 Compounds for the Treatment of Metabolic Disorders PROSIDION LIMITED (GB) 2012-03-08 US disclosed
WO-2010103334-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120059014-A1 Compounds for the Treatment of Metabolic Disorders GPR119, FFAR2, GPBAR1 GPR119 1/4885BRD4 2917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.