Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRB2 | P62993 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199203 | 0.84 | GRB2 (0.57) | GRB2NR4A1NR4A2NR4A3HPGD | |
| SCHEMBL72091 | 0.80 | CES2 (0.67) | MAPTSMN1; SMN2MAOBNR4A1NR4A2 | |
| SCHEMBL31510803 | 0.79 | GRB2 (0.50) | GRB2MAPTMAOBCES2CES1 | |
| SCHEMBL1063656 | 0.79 | TSHR (0.53) | MAPTLMNARAB9AL3MBTL1KMT2A | |
| SCHEMBL14076375 | 0.78 | SRD5A2 (0.50) | GRB2MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL18290647 | 0.78 | MAOB (0.49) | MAPTSMN1; SMN2MAOBNR4A1NR4A2 | |
| SCHEMBL5860009 | 0.78 | GRB2 (0.49) | GRB2MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL23588301 | 0.78 | CES2 (0.56) | GRB2NR4A1NR4A2NR4A3HPGD | |
| SCHEMBL13199251 | 0.78 | GRB2 (0.52) | GRB2HPGDCES2CES1KIF11 | |
| SCHEMBL15957723 | 0.78 | GRB2 (0.49) | GRB2MAPTSMN1; SMN2NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111004122-B | Synthesis method of gem-difluoroallyl compound in aqueous phase | 陕西科技大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-111004122-A | Synthesis method of gem-difluoroallyl compound in aqueous phase | 陕西科技大学 | 2020-04-14 | — | — | CN | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| EP-2502898-A1 | PREPARATION METHOD FOR AROMATIC DIFLUOROACETIC ACID ESTER | Central Glass Company, Limited (JP) | 2012-09-26 | — | — | EP | disclosed |
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | CENTRAL GLASS COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | CENTRAL GLASS COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | DDC, AADAC, FNTB | GRB2 2578/4885MAPT 3444/4885SMN1; SMN2 3468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.