Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12075521 | 0.92 | GHSR (0.51) | GHSR | |
| SCHEMBL18716729 | 0.92 | GHSR (0.53) | GHSR | |
| SCHEMBL12004458 | 0.90 | GHSR (0.57) | GHSR | |
| SCHEMBL12075515 | 0.90 | GHSR (0.57) | GHSR | |
| SCHEMBL12004800 | 0.90 | GHSR (0.57) | GHSR | |
| SCHEMBL17062636 | 0.88 | GHSR (0.53) | GHSR | |
| SCHEMBL12005228 | 0.88 | GHSR (0.53) | GHSR | |
| SCHEMBL17062885 | 0.87 | GHSR (0.69) | GHSR | |
| SCHEMBL17062675 | 0.87 | GHSR (0.54) | GHSR | |
| SCHEMBL17062656 | 0.86 | GHSR (0.51) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044293-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2018-02-15 | — | — | US | claimed |
| US-9751836-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA (CH) | 2017-09-05 | — | — | US | claimed |
| EP-2678017-B1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-04-05 | — | — | EP | claimed |
| US-20140121210-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2014-05-01 | — | — | US | claimed |
| US-8658797-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA (CH) | 2014-02-25 | — | — | US | claimed |
| US-20120220629-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2012-08-30 | — | — | US | claimed |
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | HELSINN HEALTHCARE SA (CH) | 2020-08-20 | — | — | US | disclosed |
| EP-3114118-B1 | P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2020-07-22 | — | — | EP | disclosed |
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2020-03-03 | — | — | US | disclosed |
| US-10407390-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA | 2019-09-10 | — | — | US | disclosed |
| US-10407390-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA | 2019-09-10 | — | — | US | disclosed |
| US-9926337-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2018-03-27 | — | — | US | disclosed |
| US-20180044293-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2018-02-15 | — | — | US | disclosed |
| EP-2678017-B1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-04-05 | — | — | EP | disclosed |
| US-20140121210-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2014-05-01 | — | — | US | disclosed |
| US-8658797-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA (CH) | 2014-02-25 | — | — | US | disclosed |
| US-8658797-B2 | Asymmetric ureas and medical uses thereof | HELSINN HEALTHCARE SA (CH) | 2014-02-25 | — | — | US | disclosed |
| US-20120220629-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2012-08-30 | — | — | US | disclosed |
| WO-2012116176-A2 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012113103-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE S.A. (CH) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | GHSR, GIPR, UTS2R | GHSR 1/4885 |
| US-20120220629-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GPR119, GHSR | GHSR 3/4885 |
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | GHSR, GIPR, UTS2R | GHSR 1/4885 |
| US-10407390-B2 | Asymmetric ureas and medical uses thereof | UTS2R, GPR119, GHSR | GHSR 3/4885 |
| US-20140121210-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GPR119, GHSR | GHSR 3/4885 |
| US-20180044293-A1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GPR119, GHSR | GHSR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.