⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453892 | 1.00 | — | — | |
| SCHEMBL21996 | 0.81 | — | — | |
| SCHEMBL452721 | 0.81 | — | — | |
| SCHEMBL450255 | 0.70 | — | — | |
| SCHEMBL28274290 | 0.69 | DYRK1A (0.40) | — | |
| Benzothiophene SCHEMBL27791811 | 0.67 | CA12 (0.41) | — | |
| Benzothiophene SCHEMBL20473352 | 0.67 | CA12 (0.41) | — | |
| SCHEMBL2393082 | 0.67 | GPR3 (0.39) | — | |
| Benzothiophene SCHEMBL28337252 | 0.67 | CTNNB1 (0.37) | — | |
| SCHEMBL451955 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3969 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-12-12 | — | — | US | claimed |
| EP-4149453-A1 | COMBINATION TREATMENT OF LIVER DISORDERS | Terns Pharmaceuticals, Inc. (US) | 2023-03-22 | — | — | EP | claimed |
| EP-4149452-A1 | COMBINATION TREATMENT OF LIVER DISORDERS | Terns Pharmaceuticals, Inc. (US) | 2023-03-22 | — | — | EP | claimed |
| CN-115811972-A | Combination therapy for liver disorders | 拓臻制药公司 | 2023-03-17 | — | — | CN | claimed |
| CN-115811973-A | Combination therapy for liver disorders | 拓臻制药公司 | 2023-03-17 | — | — | CN | claimed |
| US-20220227762-A1 | AMIDE-SUBSTITUTED IMIDAZO COMPOUNDS AS SELECTIVE INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2022-07-21 | — | — | US | claimed |
| US-20220024891-A1 | THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2022-01-27 | — | — | US | claimed |
| CN-109952300-B | 5-or 8-substituted imidazo [1,5-a ] pyridines | 百济神州有限公司 | 2022-01-18 | — | — | CN | claimed |
| CN-113891880-A | Amide substituted imidazo compounds as selective inhibitors of indoleamine 2, 3-dioxygenase | 百济神州有限公司 | 2022-01-04 | — | — | CN | claimed |
| WO-2021231644-A1 | COMBINATION TREATMENT OF LIVER DISORDERS | TERNS PHARMACEUTICALS, INC. (US) | 2021-11-18 | — | — | WO | claimed |
| US-5691374-A | ENZYME INHIBITORS OF CYCLOOXYGENASE AS ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA INC. (CA) | 1997-11-25 | — | — | US | claimed |
| US-5681842-A | Prostaglandin synthase-2 inhibitors | ABBOTT LABORATORIES (US) | 1997-10-28 | — | — | US | claimed |
| EP-0799218-A1 | DIARYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-10-08 | — | — | EP | claimed |
| CN-1144526-A | Thiazolidines and oxazolidines substituted by pyridine ring and their use a hypoglycemic agents | NISSAN CHEMICAL IND LTD (JP) | 1997-03-05 | — | — | CN | claimed |
| EP-0751944-A1 | THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1997-01-08 | — | — | EP | claimed |
| WO-1996036623-A1 | DIARYL-5-OXYGENATED-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-11-21 | — | — | WO | claimed |
| WO-1996035678-A1 | ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-14 | — | — | WO | claimed |
| WO-1996019469-A1 | DIARYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-06-27 | — | — | WO | claimed |
| WO-1995026347-A1 | THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-05 | — | — | WO | claimed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | claimed |