Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31303445 | 0.85 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 | |
| SCHEMBL543352 | 0.85 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL6980967 | 0.83 | ALDH1A1 (0.67) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 | |
| SCHEMBL28165708 | 0.83 | HSD17B10 (0.47) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 | |
| SCHEMBL27580293 | 0.82 | ATM (0.48) | ALDH1A1HSD17B10TSHRCYP3A4KDM4E | |
| SCHEMBL717606 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 | |
| SCHEMBL27498904 | 0.81 | TSHR (0.47) | ALDH1A1HSD17B10TSHRCYP3A4MMP2 | |
| SCHEMBL9259479 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CFTRTSHRKDM4E | |
| SCHEMBL27919811 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HSD17B10CFTRTSHRKDM4E | |
| SCHEMBL25142572 | 0.80 | HSD17B10 (0.45) | ALDH1A1HSD17B10CFTRTSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946259-B2 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2014-03-06 | — | — | US | disclosed |
| US-8598353-B2 | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-1863771-B1 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-2457901-A1 | Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors | High Point Pharmaceuticals, LLC (US) | 2012-05-30 | — | — | EP | disclosed |
| US-20110065713-A1 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-03-17 | — | — | US | disclosed |
| US-7893267-B2 | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090326006-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | VTVX HOLDINGS II LLC | 2009-12-31 | — | — | US | disclosed |
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20060223849-A1 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC | 2006-10-05 | — | — | US | disclosed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| EP-1196398-A4 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6403807-B1 | CYANINE DYES HAVING SEPARATE SECOND LINKING CHAIN JOINING TWO HETEROCYCLES TO RESTRAIN COMPOUND INTO DESIRED CONFORMATION WHICH ABSORBS ELECTROMAGNETIC ENERGY AND EMITS FLUORESCENCE AT SPECIFIED WAVELENGTHS | SURROMED, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1196398-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | Surromed, Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002374-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED, INC. (US) | 2001-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326006-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | BACE1, BACE2, APP | ALDH1A1 1717/4885HSD17B10 955/4885CFTR 2248/4885 |
| US-20110065713-A1 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors | BACE1, BACE2, APP | ALDH1A1 2426/4885HSD17B10 1119/4885CFTR 2779/4885 |
| US-20060223849-A1 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | BACE1, BACE2, APP | ALDH1A1 1717/4885HSD17B10 955/4885CFTR 2248/4885 |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | BACE1, BACE2, APP | ALDH1A1 1717/4885HSD17B10 955/4885CFTR 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.