Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311346 | 0.92 | GAA (0.51) | GAAHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL12017289 | 0.84 | GAA (0.55) | GAAHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL12442786 | 0.81 | BCHE (0.52) | LMNAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL303273 | 0.78 | HPGD (0.48) | GAAHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL3287847 | 0.76 | GAA (0.55) | GAAHPGDLMNAKMT2AMEN1 | |
| SCHEMBL12017326 | 0.75 | CA12 (0.55) | GAAHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL302980 | 0.73 | NPC1 (0.48) | GAAHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL12017314 | 0.73 | HSD11B1 (0.49) | LMNAKMT2AALDH1A1MEN1HTT | |
| SCHEMBL2526379 | 0.72 | GRIN2D (0.52) | ALDH1A1SMN1; SMN2POLBGRIN2DGRIN3B | |
| SCHEMBL18426023 | 0.72 | GRIN2D (0.52) | ALDH1A1SMN1; SMN2POLBGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | claimed |
| US-8258138-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2012-09-04 | — | — | US | claimed |
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | disclosed |