Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287847 | 0.91 | GAA (0.55) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL12017331 | 0.84 | GAA (0.51) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL3377001 | 0.80 | F10 (0.56) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL12017326 | 0.79 | CA12 (0.55) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL3377438 | 0.78 | LMNA (0.54) | LMNAHPGDHTTKMT2AF10 | |
| SCHEMBL311346 | 0.76 | GAA (0.51) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL14597201 | 0.76 | ACHE (0.61) | LMNAHPGDHTTKMT2AMEN1 | |
| SCHEMBL1722441 | 0.76 | LMNA (0.53) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL303273 | 0.76 | HPGD (0.48) | GAALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL13064474 | 0.72 | KMT2A (0.63) | GAALMNAHPGDHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | claimed |
| US-8258138-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2012-09-04 | — | — | US | claimed |
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | disclosed |