SCHEMBL12019012

SCHEMBL12019012

O=C1CCCCC1C1=CCCC=C1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TLR4 O00206 1/20 0.40
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
KMT2A Q03164 1/20 0.34
ALDH1A1 P00352 1/20 0.32
MCL1 Q07820 1/20 0.31
MAPT P10636 1/20 0.30
HCAR1 Q9BXC0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8874668 0.71 TLR4 (0.55) TLR4CA1CA2CA4KMT2A
SCHEMBL9656006 0.70 TLR4 (0.36) TLR4CA1CA2CA4KMT2A
SCHEMBL9294037 0.68 ESR2 (0.37) ALDH1A1
SCHEMBL30130600 0.68 TLR4 (0.56) TLR4CA1CA2CA4KMT2A
SCHEMBL130772 0.68 TLR4 (0.56) TLR4CA1CA2CA4KMT2A
SCHEMBL15435520 0.68 PDE4A (0.34)
SCHEMBL25569054 0.68 TLR4 (0.40) TLR4CA1CA2CA4KMT2A
SCHEMBL22746302 0.66 TLR4 (0.35) TLR4CA1CA2CA4KMT2A
SCHEMBL11443954 0.66 TLR4 (0.58) TLR4CA1CA2CA4KMT2A
SCHEMBL22888037 0.66 HCRTR2 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2208519-B1 Agent for separating optical isomers DAICEL CHEM (JP) 2012-08-29 EP disclosed