Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12021892 | 0.87 | L3MBTL1 (0.57) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL14363620 | 0.85 | L3MBTL1 (0.62) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL7601476 | 0.83 | L3MBTL1 (0.61) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL25384005 | 0.81 | L3MBTL1 (0.57) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL27364860 | 0.81 | L3MBTL1 (0.57) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL8282389 | 0.81 | L3MBTL1 (0.57) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL8418331 | 0.80 | L3MBTL1 (0.61) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL19728838 | 0.79 | L3MBTL1 (0.56) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL8226427 | 0.79 | L3MBTL1 (0.56) | L3MBTL1CA12CA1CA2CA9 | |
| SCHEMBL8226165 | 0.77 | L3MBTL1 (0.57) | L3MBTL1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934227-B1 | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2011-12-21 | — | — | EP | disclosed |