Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046687 | 0.81 | CRHR1 (0.41) | LMNACRHR1ALDH1A1 | |
| SCHEMBL5844440 | 0.77 | CRHR1 (0.43) | MAPTCYP3A4MAPK1CRHR1 | |
| SCHEMBL12027414 | 0.72 | MEN1 (0.42) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11365693 | 0.67 | PPIA (0.37) | MAPTL3MBTL1TDP1GAAKMT2A | |
| SCHEMBL11363707 | 0.67 | GAA (0.40) | MAPTLMNATDP1GAAHTT | |
| SCHEMBL13329903 | 0.67 | TAAR1 (0.63) | MAPTLMNATDP1GAAKMT2A | |
| SCHEMBL27690591 | 0.67 | MAPT (0.48) | MAPTCYP3A4LMNAL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL11262372 | 0.66 | MAPT (0.40) | MAPTLMNATDP1GAAHTT | |
| Hydrochloric Acid SCHEMBL11369618 | 0.66 | PPIA (0.36) | MAPTL3MBTL1TDP1GAAKMT2A | |
| SCHEMBL5842958 | 0.66 | CRHR1 (0.50) | TDP1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179919-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140179919-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2014-06-26 | — | — | US | disclosed |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | UNIV EMORY (US) | 2013-10-31 | — | — | US | disclosed |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | UNIV EMORY (US) | 2013-10-31 | — | — | US | disclosed |
| US-8551996-B2 | Compounds, compositions, methods of synthesis, and methods of treatment | EMORY UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-8551996-B2 | Compounds, compositions, methods of synthesis, and methods of treatment | EMORY UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | EMORY UNIVERSITY (US) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179919-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | MAPT 2625/4885CYP1A2 2127/4885CYP3A4 2207/4885 |
| US-20110305636-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | MAPT 2261/4885CYP1A2 2813/4885CYP3A4 2668/4885 |
| US-20130287687-A1 | COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT | CRH, CRHR1, CRHR2 | MAPT 2625/4885CYP1A2 2127/4885CYP3A4 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.