Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 7/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ACACA | Q13085 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801267 | 0.94 | ITK (0.49) | ITKACACBCRBNMEN1KMT2A | |
| SCHEMBL24671204 | 0.94 | ITK (0.49) | ITKACACBCRBNMEN1KMT2A | |
| SCHEMBL23808291 | 0.89 | ITK (0.43) | ITKACACBKDRMEN1KMT2A | |
| SCHEMBL12028506 | 0.88 | ITK (0.49) | ITKACACBKDRPIP5K1CMGLL | |
| SCHEMBL12028510 | 0.87 | ITK (0.48) | ITKKDRPIP5K1CPARP1MGLL | |
| SCHEMBL12028517 | 0.87 | ITK (0.50) | ITKACACBKDRKMT2APIP5K1C | |
| SCHEMBL25190175 | 0.86 | ITK (0.47) | ITKACACBPIP5K1CPARP1 | |
| SCHEMBL25190449 | 0.86 | ITK (0.47) | ITKACACBPIP5K1CPARP1 | |
| SCHEMBL12028443 | 0.86 | ITK (0.56) | ITKKDRPIP5K1C | |
| SCHEMBL12028453 | 0.85 | ITK (0.47) | ITKKDRPIP5K1CPARP1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255408-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2020-08-13 | — | — | US | disclosed |
| US-20170267662-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2017-09-21 | — | — | US | disclosed |
| US-20170267662-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2017-09-21 | — | — | US | disclosed |
| EP-2505586-B1 | INDOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2016-03-02 | — | — | EP | disclosed |
| US-20130116240-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2013-05-09 | — | — | US | disclosed |
| US-20130116240-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2013-05-09 | — | — | US | disclosed |
| US-8299070-B2 | Indole compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2012-10-30 | — | — | US | disclosed |
| US-8299070-B2 | Indole compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20110306599-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2011-12-15 | — | — | US | disclosed |
| US-20110306599-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255408-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | IDO1, IDO2, INMT | ITK 732/4885ACACB 2783/4885CRBN 2253/4885 |
| US-20130116240-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | IDO1, IDO2, INMT | ITK 732/4885ACACB 2783/4885CRBN 2253/4885 |
| US-20170267662-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | IDO1, IDO2, INMT | ITK 1309/4885ACACB 3340/4885CRBN 2556/4885 |
| US-20110306599-A1 | INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | IDO1, IDO2, INMT | ITK 732/4885ACACB 2783/4885CRBN 2253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.