Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 14/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202738 | 0.90 | IRAK4 (0.41) | NAMPTIRAK4NTRK1 | |
| SCHEMBL2899563 | 0.80 | NTRK1 (0.41) | IRAK4NTRK1 | |
| SCHEMBL1203002 | 0.78 | PTPN11 (0.44) | FYNIRAK4NTRK1 | |
| SCHEMBL1202773 | 0.77 | FYN (0.51) | FYNIRAK4NTRK1 | |
| SCHEMBL1203710 | 0.76 | CLK1 (0.43) | NAMPTIRAK4NTRK1 | |
| SCHEMBL1202338 | 0.75 | FYN (0.66) | FYNIRAK4NTRK1 | |
| SCHEMBL1203816 | 0.73 | CXCR1 (0.52) | FYNNTRK1 | |
| SCHEMBL1203496 | 0.72 | PTPN11 (0.53) | IRAK4 | |
| SCHEMBL1203662 | 0.72 | NTRK1 (0.39) | IRAK4NTRK1 | |
| SCHEMBL1203791 | 0.70 | ALDH1A1 (0.46) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | FYN 403/4885NAMPT 3511/4885IRAK4 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.