Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12029979 | 0.86 | MALT1 (0.37) | THRBPOLBMAPTKMT2AMEN1 | |
| SCHEMBL14609831 | 0.86 | THRB (0.46) | KDM4EATMHTTTHRBPTGS1 | |
| SCHEMBL16498966 | 0.84 | MAPT (0.40) | KDM4EATMPOLBMAPTKMT2A | |
| SCHEMBL768905 | 0.84 | POLB (0.39) | KDM4EPTGS1PTGS2POLBMAPT | |
| SCHEMBL12461449 | 0.83 | ACACB (0.49) | KDM4EATMHTTPTGS1PTGS2 | |
| SCHEMBL14432214 | 0.83 | MAPT (0.36) | THRBPOLBMAPTTP53 | |
| SCHEMBL16498547 | 0.83 | MAPT (0.41) | THRBPOLBMAPTALDH1A1TP53 | |
| SCHEMBL12029780 | 0.82 | ACACB (0.39) | THRBTP53ACACBACACA | |
| SCHEMBL9883939 | 0.82 | POLB (0.41) | KDM4EATMHTTTHRBPOLB | |
| SCHEMBL2356692 | 0.81 | ACACB (0.49) | THRBACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000189-B2 | Biphenyl-substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2015-04-07 | — | — | US | disclosed |
| US-20110306499-A1 | Biphenyl-Substituted Spirocyclic Ketoenols | BAYER CROPSCIENCE AG (DE) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306499-A1 | Biphenyl-Substituted Spirocyclic Ketoenols | KCNE1, PDHX, PIKFYVE | KDM4E 70/4885ATM 2974/4885HTT 2302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.