Rivanicline

Rivanicline

SCHEMBL120434

CNCC/C=C/c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 5/20 1.00
CHRNA4 P43681 5/20 1.00
CHRNB4 P30926 2/20 1.00
CHRNA3 P32297 2/20 1.00
CHRNA7 P36544 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C9 P11712 1/20 1.00
ALOX15 P16050 1/20 1.00
CYP2C19 P33261 1/20 1.00
TBXAS1 P24557 1/20 0.52
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
KDM4E B2RXH2 1/20 0.45
JUN P05412 1/20 0.45
MAPT P10636 1/20 0.45
NFKB1 P19838 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rivanicline SCHEMBL29379231 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Rivanicline SCHEMBL120435 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Rivanicline SCHEMBL29423002 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Rivanicline SCHEMBL7743987 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Rivanicline SCHEMBL6260928 0.91 CHRNB2 (0.83) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Rivanicline SCHEMBL29615748 0.91 CHRNB2 (0.83) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL7743553 0.90 CHRNB2 (0.82) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL5701133 0.90 CHRNB2 (0.82) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL5701137 0.90 CHRNB2 (0.82) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL6258763 0.83 CHRNB2 (0.70) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 891 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250221968-A1 TREATMENTS AND METHODS FOR INCREASING DOPAMINE UNIV OXFORD INNOVATION LTD (GB) 2025-07-10 US claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
EP-4493171-A1 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST/BLOCKER FOR USE IN INCREASING DOPAMINE Zhang, Yanfeng C/o Oxford University Innovation Limited (GB) 2025-01-22 EP claimed
CN-119212689-A Nicotinic acetylcholine receptor antagonists/blockers for increasing dopamine 张燕峰 2024-12-27 CN claimed
WO-2023175357-A1 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST/BLOCKER FOR USE IN INCREASING DOPAMINE OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2023-09-21 WO claimed
US-20210077478-A1 METHOD OF COUNTERING RESPIRATORY DEPRESSION VIA ACTIVATION OF NEURONAL HETEROMERIC NICOTINIC ACETYLCHOLINE RECEPTORS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2021-03-18 US claimed
US-20210060123-A1 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN LEVICEPT LTD (GB) 2021-03-04 US claimed
EP-3713574-A1 METHOD OF COUNTERING RESPIRATORY DEPRESSION VIA ACTIVATION OF NEURONAL HETEROMERIC NICOTINIC ACETYLCHOLINE RECEPTORS The Governors of the University of Alberta (CA) 2020-09-30 EP claimed
CN-111629726-A Method for combatting respiratory depression by activating neuronal heterotopic nicotinic acetylcholine receptors 阿尔伯塔大学理事会 2020-09-04 CN claimed
WO-2019100155-A1 METHOD OF COUNTERING RESPIRATORY DEPRESSION VIA ACTIVATION OF NEURONAL HETEROMERIC NICOTINIC ACETYLCHOLINE RECEPTORS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2019-05-31 WO claimed
US-20090111837-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PFIZER INC. 2009-04-30 US claimed
EP-1855686-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN Pfizer Limited (GB) 2007-11-21 EP claimed
WO-2006092691-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PFIZER LIMITED (GB) 2006-09-08 WO claimed
EP-1011672-B1 USE OF (E)-METANICOTINE DERIVATIVES FOR ELICITING ANALGESIC EFFECTS UNIV VIRGINIA COMMONWEALTH (US) 2005-10-19 EP claimed
EP-1126846-B1 Use of a nicotine receptor agonist for the manufacture of a medicament for the treatment of obsessive compulsive disorder CARLSSON A RESEARCH AB (SE) 2003-08-06 EP claimed
EP-1011672-A4 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS UNIV VIRGINIA COMMONWEALTH (US) 2001-04-04 EP claimed
US-6117891-A ADMINISTERING TO A PATIENT AN EFFECTIVE AMOUNT OF A PYRIDINE-OR PYRIMIDINE-SUBSTITUTED OLEFIN VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-09-12 US claimed
EP-1011672-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-06-28 EP claimed
US-5914337-A Compounds and pharmaceutical compositions thereof for eliciting analgesic effects VIRGINIA COMMONWEALTH UNIVERSITY (US) 1999-06-22 US claimed
WO-1999007369-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR ELICITING ANALGESIC EFFECTS VIRGINIA COMMONWEALTH UNIVERSITY (US) 1999-02-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE TACR1, ACHE, TACR2 CHRNB2 64/4885CHRNA4 91/4885CHRNB4 104/4885
US-20090111837-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PDE7A, PDE7B, PDE3A CHRNB2 433/4885CHRNA4 307/4885CHRNB4 406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.