Tyrphostin A9

Tyrphostin A9

SCHEMBL120440

CC(C)(C)c1cc(C=C(C#N)C#N)cc(C(C)(C)C)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 1.00
KMT2A Q03164 8/20 1.00
MAPT P10636 7/20 1.00
CYP3A4 P08684 6/20 1.00
BLM P54132 6/20 1.00
SMN1; SMN2 Q16637 6/20 1.00
HSD17B10 Q99714 6/20 1.00
ALDH1A1 P00352 6/20 1.00
LMNA P02545 6/20 1.00
TSHR P16473 5/20 1.00
CYP2C9 P11712 5/20 1.00
HPGD P15428 5/20 1.00
ALOX15 P16050 5/20 1.00
NFKB1 P19838 5/20 1.00
PMP22 Q01453 5/20 1.00
HIF1A Q16665 5/20 1.00
RGS12 O14924 4/20 1.00
GNAI1 P63096 4/20 1.00
TP53 P04637 4/20 1.00
THPO P40225 4/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10144541 0.89 CISD1 (1.00) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL11759421 0.89 MEN1 (0.79) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL11760765 0.89 MEN1 (0.79) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL29351372 0.89 CISD1 (1.00) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL25800807 0.86 MEN1 (0.74) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL13941361 0.84 SMN1; SMN2 (0.72) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL22697129 0.84 SMN1; SMN2 (0.72) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL22817483 0.81 MAPT (0.68) MEN1KMT2AMAPTCYP3A4BLM
SCHEMBL21549473 0.80 MAPT (0.66) MEN1KMT2AMAPTCYP3A4BLM
Tyrphostin Ag 879 SCHEMBL607701 0.78 MAPT (1.00) MEN1KMT2AMAPTCYP3A4BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4748 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107237-A1 RAS AND EGFR INHIBITORS COMBINATION THERAPY ERASCA, INC. (US) 2026-05-21 WO claimed
US-20260137082-A1 FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL SYNGENTA CROP PROTECTION AG (CH) 2026-05-21 US claimed
WO-2025244856-A1 METHODS AND COMPOSITIONS RELATING TO ELQ COMPOUNDS OREGON HEALTH & SCIENCE UNIVERSITY (US) 2025-11-27 WO claimed
EP-3060043-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS CORTEVA AGRISCIENCE LLC (US) 2025-11-26 EP claimed
US-12471599-B2 Agricultural compositions comprising remodeled nitrogen fixing microbes PIVOT BIO, INC. (US) 2025-11-18 US claimed
EP-3578542-B1 COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-11-12 EP claimed
EP-4627920-A1 BINARY INSECTICIDE COMPOSITION AND USE THEREOF Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) 2025-10-08 EP claimed
EP-4615869-A1 COMBINATION THERAPY COMPRISING BISPECIFIC ANTIBODIES COMPRISING AN NRP1 BINDING DOMAIN Pinetree Therapeutics, Inc. (US) 2025-09-17 EP claimed
EP-3578543-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-08-20 EP claimed
US-20250185667-A1 AGRICULTURAL COMPOSITIONS COMPRISING REMODELED NITROGEN FIXING MICROBES HSBC BANK USA, N.A. 2025-06-12 US claimed
US-20030198659-A1 Fibrous pest control CORNELL RESEARCH FOUNDATION, INC. 2003-10-23 US claimed
EP-1156775-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2001-11-28 EP claimed
EP-0856735-B1 Colour staining reagent for blood cells ABX SA (FR) 2001-04-25 EP claimed
US-6121269-A TOPICALLY APPLYING A PROTEIN-TYROSINE KINASE INHIBITOR TO SKIN TO REDUCE ANDROGEN-STIMULATED HAIR GROWTH WITHOUT SIDE EFFECTS GILLETTE COMPANY, THE, A DELAWARE CORPORATION 2000-09-19 US claimed
WO-2000050002-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2000-08-31 WO claimed
US-5994138-A CONTAINS A STAIN CAPABLE OF LABELLING CELLS AFTER INCUBATION, AS WELL AS AN ADDITIVE WHICH IS ABLE TO ENCOURAGE PENETRATION OF THE STAIN INTO THE CELLS, THIS ADDITIVE BEING CHOSEN FROM AN IONOPHORIC COMPOUND, A DETERGENT AND MIXTURES THEREOF ABX (FR) 1999-11-30 US claimed
EP-0856735-A1 Colour staining reagent for blood cells ABX (FR) 1998-08-05 EP claimed
EP-0614661-A2 Benzylidene- and cinnamylidine-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1994-09-14 EP claimed
EP-0322738-A2 Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1989-07-05 EP claimed
EP-0074198-A1 Hydrogen ion-selective membranes and electrodes containing same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-03-16 EP claimed