Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046634 | 0.85 | CCNA2 (0.44) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL12046645 | 0.85 | KCNK3 (0.42) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL12060227 | 0.85 | MAPT (0.44) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL15850622 | 0.84 | CCNA2 (0.55) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL15850651 | 0.84 | CCNA2 (0.45) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL1199601 | 0.84 | PDE7A (0.43) | KCNK3MAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL12046655 | 0.83 | SLC5A1 (0.43) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL12046640 | 0.83 | ALDH1A1 (0.52) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL12046650 | 0.83 | CCNA2 (0.46) | KCNK3CCNA2CDK2CCNA1MAPT | |
| SCHEMBL12046651 | 0.83 | CCNA2 (0.44) | KCNK3CCNA2CDK2CCNA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| WO-2011012674-A1 | DIHYDROBENZOINDAZOLES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028451-A1 | Dihydrobenzoindazoles | DHODH, BRDT, HSD17B11 | KCNK3 555/4885CCNA2 4115/4885CDK2 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.