Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046655 | 0.92 | SLC5A1 (0.43) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL12060226 | 0.89 | KDM4E (0.39) | CCNA2CDK2CCNA1ALDH1A1KDM4E | |
| SCHEMBL15850622 | 0.86 | CCNA2 (0.55) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL15850651 | 0.85 | CCNA2 (0.45) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL12046648 | 0.85 | KCNK3 (0.48) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL12046640 | 0.84 | ALDH1A1 (0.52) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL12046651 | 0.84 | CCNA2 (0.44) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL12046650 | 0.84 | CCNA2 (0.46) | MAPTMAPK1KCNK3CCNA2CDK2 | |
| SCHEMBL1160322 | 0.84 | PDE10A (0.41) | CA2 | |
| SCHEMBL12046643 | 0.84 | KCNK3 (0.40) | MAPTMAPK1KCNK3CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |