Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | CHAT | P28329 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307892 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19DHODH | |
| SCHEMBL20307886 | 0.81 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL8550458 | 0.79 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C9CYP2C19DHODH | |
| SCHEMBL16471841 | 0.77 | MAPT (0.48) | ALDH1A1CYP1A2CYP2C9CYP2C19ADRA2A | |
| SCHEMBL29159451 | 0.77 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL6006538 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL3736958 | 0.75 | CYP2C9 (0.42) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL3736965 | 0.75 | CYP2C9 (0.42) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL3736960 | 0.75 | CYP2C9 (0.42) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 | |
| SCHEMBL25991088 | 0.73 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406211-B1 | A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF | MEGAFINE PHARMA P LTD (IN) | 2018-06-27 | — | — | EP | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-8575395-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575395-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | ALDH1A1 3/4885CYP1A2 636/4885CYP2C9 172/4885 |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | ALDH1A1 3/4885CYP1A2 636/4885CYP2C9 172/4885 |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | ALDH1A1 3/4885CYP1A2 636/4885CYP2C9 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.