Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 7/20 | 0.55 |
| ▸ | FDPS | P14324 | 9/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060530 | 0.94 | GGPS1 (0.58) | GGPS1FDPSCYP3A4CYP2D6CYP19A1 | |
| SCHEMBL12048205 | 0.86 | GGPS1 (0.59) | GGPS1FDPS | |
| SCHEMBL12048173 | 0.86 | GGPS1 (0.56) | GGPS1FDPSS1PR1RARB | |
| SCHEMBL12048146 | 0.84 | GGPS1 (0.76) | GGPS1FDPS | |
| SCHEMBL14199552 | 0.83 | GGPS1 (0.63) | GGPS1FDPS | |
| SCHEMBL12060540 | 0.80 | GGPS1 (0.63) | GGPS1FDPS | |
| SCHEMBL12060365 | 0.80 | GGPS1 (0.59) | GGPS1FDPSS1PR1RARB | |
| SCHEMBL12048208 | 0.80 | GGPS1 (0.59) | GGPS1FDPS | |
| SCHEMBL12048161 | 0.80 | GGPS1 (0.59) | GGPS1FDPS | |
| SCHEMBL12048151 | 0.79 | GGPS1 (0.78) | GGPS1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |