Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 6/20 | 0.76 |
| ▸ | FDPS | P14324 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.37 |
| ▸ | CHRNA10 | Q9GZZ6 | 6/20 | 0.37 |
| ▸ | CHRNA9 | Q9UGM1 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12048151 | 0.95 | GGPS1 (0.78) | GGPS1FDPSLMNAHTTRAB9A | |
| SCHEMBL12060352 | 0.91 | GGPS1 (0.84) | GGPS1FDPSLMNAHTTRAB9A | |
| SCHEMBL14199552 | 0.91 | GGPS1 (0.63) | GGPS1FDPSLMNAHTTRAB9A | |
| SCHEMBL12048188 | 0.90 | GGPS1 (0.62) | GGPS1FDPSLMNAKDM4EALDH1A1 | |
| SCHEMBL12048205 | 0.87 | GGPS1 (0.59) | GGPS1FDPSLMNARAB9AALDH1A1 | |
| SCHEMBL12048208 | 0.87 | GGPS1 (0.59) | GGPS1FDPSLMNAHTTRAB9A | |
| SCHEMBL12048161 | 0.87 | GGPS1 (0.59) | GGPS1FDPSPTPN5 | |
| SCHEMBL12048185 | 0.87 | GGPS1 (0.57) | GGPS1FDPSPTPN5 | |
| SCHEMBL12060355 | 0.86 | GGPS1 (0.85) | GGPS1FDPSLMNAHTTRAB9A | |
| SCHEMBL12048173 | 0.84 | GGPS1 (0.56) | GGPS1FDPSCHRNA7CHRNA10CHRNA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |