Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12048146 | 0.87 | GGPS1 (0.76) | GGPS1SMN1; SMN2FDPSLMNAKDM4E | |
| SCHEMBL14199552 | 0.86 | GGPS1 (0.63) | GGPS1SMN1; SMN2FDPSLMNAKDM4E | |
| SCHEMBL12048188 | 0.85 | GGPS1 (0.62) | GGPS1FDPSLMNAKDM4EALDH1A1 | |
| SCHEMBL12048161 | 0.83 | GGPS1 (0.59) | GGPS1FDPS | |
| SCHEMBL12048205 | 0.83 | GGPS1 (0.59) | GGPS1FDPSLMNAALDH1A1RAB9A | |
| SCHEMBL12048151 | 0.83 | GGPS1 (0.78) | GGPS1SMN1; SMN2FDPSLMNARAB9A | |
| SCHEMBL12048173 | 0.81 | GGPS1 (0.56) | GGPS1FDPS | |
| SCHEMBL12048201 | 0.80 | GGPS1 (0.55) | GGPS1FDPS | |
| SCHEMBL12060352 | 0.79 | GGPS1 (0.84) | GGPS1SMN1; SMN2FDPSLMNARAB9A | |
| SCHEMBL12060371 | 0.77 | GGPS1 (0.67) | GGPS1FDPSLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |