Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 7/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060548 | 0.94 | GGPS1 (0.62) | GGPS1HDAC4HDAC8FDPSSLC13A5 | |
| SCHEMBL12048205 | 0.88 | GGPS1 (0.59) | GGPS1HDAC4HDAC8FDPS | |
| SCHEMBL12048171 | 0.87 | GGPS1 (0.49) | GGPS1FDPS | |
| SCHEMBL12048151 | 0.86 | GGPS1 (0.78) | GGPS1FDPSPTPN5 | |
| SCHEMBL12048146 | 0.83 | GGPS1 (0.76) | GGPS1FDPSPTPN5 | |
| SCHEMBL12060540 | 0.82 | GGPS1 (0.63) | GGPS1HDAC4HDAC8FDPS | |
| SCHEMBL12060353 | 0.80 | GGPS1 (0.52) | GGPS1FDPS | |
| SCHEMBL14199552 | 0.80 | GGPS1 (0.63) | GGPS1FDPSPTPN5 | |
| SCHEMBL12048188 | 0.79 | GGPS1 (0.62) | GGPS1FDPSPTPN5 | |
| SCHEMBL12060355 | 0.78 | GGPS1 (0.85) | GGPS1FDPSPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |