⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12769536 | 1.00 | — | — | |
| SCHEMBL10072848 | 0.88 | — | — | |
| SCHEMBL12049855 | 0.71 | — | — | |
| SCHEMBL12769538 | 0.71 | — | — | |
| SCHEMBL13900379 | 0.70 | — | — | |
| SCHEMBL24487744 | 0.69 | TSHR (0.32) | — | |
| SCHEMBL13146126 | 0.69 | CA2 (0.33) | — | |
| SCHEMBL1038767 | 0.69 | CA2 (0.33) | — | |
| SCHEMBL12049857 | 0.69 | L3MBTL1 (0.31) | — | |
| SCHEMBL12769537 | 0.69 | L3MBTL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071567-B2 | 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication | ROCHE PALO ALTO LLC (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100003213-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | DEVOS RENE ROBERT | 2010-01-07 | — | — | US | disclosed |