Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2069324 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL133521 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL2070396 | 0.84 | MAPT (0.65) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL2069790 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL329814 | 0.81 | XDH (0.55) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL7509276 | 0.81 | MAPT (0.58) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL151650 | 0.81 | MAPT (0.54) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4300808 | 0.80 | MAPT (0.61) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL1724568 | 0.78 | MAPT (0.85) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL2604722 | 0.78 | ALDH1A1 (0.72) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084628-B2 | Substituted chroman derivatives, medicaments and use in therapy | MARSHALL EDWARDS, INC. (US) | 2011-12-27 | — | — | US | disclosed |