Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 14/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057672 | 0.84 | PTGES (0.39) | PTGESPTGS2IRAK4SYK | |
| SCHEMBL12058062 | 0.84 | JAK1 (0.34) | PTGESIRAK4SYK | |
| SCHEMBL12058070 | 0.84 | IRAK4 (0.43) | PTGESPTGS2IRAK4 | |
| SCHEMBL12058194 | 0.83 | IRAK4 (0.37) | PTGESPTGS2IRAK4SYK | |
| SCHEMBL12058058 | 0.82 | PTGES (0.33) | PTGESIRAK4SYK | |
| SCHEMBL12057969 | 0.81 | APP (0.37) | PTGESPTGS2IRAK4SYK | |
| SCHEMBL12037599 | 0.81 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL12058054 | 0.81 | IRAK4 (0.37) | PTGESPTGS2IRAK4SYK | |
| SCHEMBL12057979 | 0.81 | PTPN11 (0.35) | PTGESIRAK4SYK | |
| SCHEMBL12057752 | 0.81 | MKNK1 (0.36) | PTGESPTGS2IRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110318305-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME LLC | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318305-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | PNP, XDH, PNPO | PTGES 2502/4885PTGS2 4386/4885IRAK4 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.