Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059383 | 0.91 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059604 | 0.90 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL6922755 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059378 | 0.88 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059784 | 0.87 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059607 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059792 | 0.86 | RAB9A (0.42) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059594 | 0.86 | RAB9A (0.39) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059375 | 0.85 | KDM4E (0.41) | SMN1; SMN2ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL12059143 | 0.85 | TDP1 (0.47) | ALDH1A1KDM4EHPGDL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | GRM5, GRM2, GRM1 | SMN1; SMN2 636/4885ALDH1A1 1721/4885KDM4E 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.