Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.44 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062133 | 0.88 | SLC6A4 (0.45) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062176 | 0.88 | PSEN1 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL17277326 | 0.87 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL20082493 | 0.85 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062152 | 0.82 | SLC6A2 (0.44) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062129 | 0.82 | SLC6A2 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL549100 | 0.80 | CNR1 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062002 | 0.78 | PSEN1 (0.50) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062182 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 | |
| SCHEMBL12062033 | 0.78 | SLC6A2 (0.52) | SLC6A2SLC6A4KCNH2SLC6A3PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | MPO, LPO, CAT | SLC6A2 3776/4885SLC6A4 4116/4885KCNH2 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.