Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.55 |
| ▸ | BTK | Q06187 | 6/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 10/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.51 |
| ▸ | BLK | P51451 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698053 | 0.86 | BRAF (0.68) | BRAFCYP2C9 | |
| SCHEMBL13838142 | 0.82 | RAB9A (0.53) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL10092868 | 0.81 | CSF1R (0.55) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL13837913 | 0.78 | CSF1R (0.53) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL3074483 | 0.77 | LCK (0.71) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL2501251 | 0.75 | LCK (0.72) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL1698108 | 0.75 | BRAF (0.68) | BRAFCYP2C9 | |
| SCHEMBL18618394 | 0.74 | LCK (0.69) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL3941263 | 0.74 | LCK (0.69) | LCKBTKMAPK14KDRABL1 | |
| SCHEMBL1697994 | 0.73 | BRAF (0.74) | LCKMAPK14ABL1KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147764-A1 | THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS | N.V. ORGANON (NL) | 2011-12-01 | — | — | WO | disclosed |