Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10092868 | 0.84 | CSF1R (0.55) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL13838142 | 0.83 | RAB9A (0.53) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL12065276 | 0.78 | LCK (0.55) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL12858422 | 0.75 | MEN1 (0.73) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL374471 | 0.74 | PTGS1 (0.70) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL26074343 | 0.74 | HDAC8 (0.64) | CSF1RLCKKITMAPK14KDR | |
| SCHEMBL22548671 | 0.73 | MEN1 (0.67) | CSF1RLCKBTKKITMAPK14 | |
| Hydrochloric Acid SCHEMBL5004557 | 0.73 | PTGS1 (0.68) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL13837940 | 0.73 | EPHB4 (0.51) | CSF1RLCKBTKKITMAPK14 | |
| SCHEMBL24249928 | 0.73 | MEN1 (0.70) | CSF1RLCKBTKKITMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012148792-A1 | HETEROCYCLIC COMPOUNDS AS B-RAF INHIBITORS FOR TREATMENT OF CANCER | MERCK SHARP & DOHME CORP. (US) | 2012-11-01 | — | — | WO | disclosed |