Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 8/20 | 0.60 |
| ▸ | KIT | P10721 | 9/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986093 | 0.79 | BRAF (0.41) | BRAFTNNI3KNPY5RUSP2LMNA | |
| SCHEMBL12065588 | 0.75 | TNNI3K (1.00) | BRAFTNNI3KLMNASMN1; SMN2 | |
| SCHEMBL12067164 | 0.75 | TNNI3K (1.00) | BRAFTNNI3K | |
| SCHEMBL12065587 | 0.73 | TNNI3K (0.78) | BRAFTNNI3K | |
| SCHEMBL12065842 | 0.73 | TNNI3K (0.77) | BRAFTNNI3KKIT | |
| SCHEMBL12065586 | 0.73 | TNNI3K (1.00) | BRAFTNNI3K | |
| SCHEMBL12065592 | 0.71 | TNNI3K (0.52) | BRAFTNNI3KKIT | |
| SCHEMBL12067156 | 0.70 | TNNI3K (0.43) | BRAFTNNI3K | |
| SCHEMBL12517826 | 0.69 | TNNI3K (0.58) | TNNI3K | |
| SCHEMBL12065795 | 0.67 | BRAF (0.53) | BRAFTNNI3KKITNPY5RPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |