Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.52 |
| ▸ | BRAF | P15056 | 9/20 | 0.52 |
| ▸ | AKT1 | P31749 | 5/20 | 0.45 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067156 | 0.89 | TNNI3K (0.43) | TNNI3KBRAFPNMT | |
| SCHEMBL9985737 | 0.73 | XIAP (0.39) | TNNI3KBRAFPNMT | |
| SCHEMBL14323880 | 0.72 | TNNI3K (0.40) | TNNI3KBRAFPNMT | |
| SCHEMBL12065583 | 0.71 | BRAF (0.60) | TNNI3KBRAFKIT | |
| SCHEMBL12067179 | 0.69 | TNNI3K (0.71) | TNNI3KBRAF | |
| SCHEMBL12065841 | 0.69 | TNNI3K (1.00) | TNNI3KBRAF | |
| SCHEMBL12067174 | 0.67 | TNNI3K (0.73) | TNNI3KBRAF | |
| SCHEMBL12067186 | 0.67 | TNNI3K (0.74) | TNNI3KBRAF | |
| SCHEMBL12067180 | 0.67 | TNNI3K (0.74) | TNNI3KBRAF | |
| SCHEMBL12359482 | 0.67 | XIAP (0.43) | TNNI3KBRAFPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |