Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067531 | 0.90 | PTPN11 (0.45) | PTPN11GPR119MAP3K11 | |
| SCHEMBL15154751 | 0.86 | MAP3K11 (0.47) | PTPN11GPR119MAP3K11 | |
| SCHEMBL12066045 | 0.83 | PTPN11 (0.47) | PTPN11MAP3K11 | |
| SCHEMBL30280390 | 0.77 | PTPN11 (0.42) | PTPN11ACHE | |
| SCHEMBL22324681 | 0.77 | PTPN11 (0.47) | PTPN11GPR119MAP3K11 | |
| SCHEMBL31396526 | 0.76 | PTPN11 (0.41) | PTPN11GPR119 | |
| SCHEMBL7907976 | 0.76 | PTPN11 (0.50) | PTPN11 | |
| SCHEMBL7515012 | 0.76 | MAP3K11 (0.55) | PTPN11MAP3K11 | |
| SCHEMBL12066665 | 0.76 | MAP3K11 (0.47) | PTPN11MAP3K11 | |
| SCHEMBL12066674 | 0.75 | PTPN11 (0.49) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |