Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066674 | 0.87 | PTPN11 (0.49) | PTPN11PIK3CDBRD4L3MBTL1MAP4K1 | |
| SCHEMBL7907052 | 0.85 | PTPN11 (0.46) | PTPN11PIK3CDBRD4L3MBTL1RIPK3 | |
| SCHEMBL7905360 | 0.85 | PTPN11 (0.46) | PTPN11PIK3CDBRD4L3MBTL1RIPK3 | |
| SCHEMBL12066045 | 0.85 | PTPN11 (0.47) | PTPN11BRD4 | |
| SCHEMBL12066665 | 0.85 | MAP3K11 (0.47) | PTPN11PIK3CDMAP4K1IDO1 | |
| SCHEMBL22971790 | 0.81 | PTPN11 (0.54) | PTPN11BRD4L3MBTL1KDM4EUBE2N | |
| SCHEMBL22324663 | 0.80 | PTPN11 (0.53) | PTPN11BRD4L3MBTL1KDM4EUBE2N | |
| SCHEMBL30280395 | 0.80 | PTPN11 (0.51) | PTPN11 | |
| SCHEMBL721797 | 0.80 | PTPN11 (0.51) | PTPN11 | |
| SCHEMBL7910236 | 0.79 | PTPN11 (0.40) | PTPN11PIK3CDBRD4L3MBTL1RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |