Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 1/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9983118 | 0.91 | BTK (0.46) | BTKJAK2AURKALCKLYN | |
| SCHEMBL12071461 | 0.85 | GABRG2 (0.43) | BTKJAK2AURKALCKLYN | |
| SCHEMBL9983438 | 0.80 | JAK2 (0.46) | BTKJAK2AURKALCKLYN | |
| SCHEMBL12071967 | 0.78 | BTK (0.43) | BTKJAK2AURKALCKLYN | |
| SCHEMBL9983448 | 0.78 | JAK2 (0.53) | BTKJAK2AURKALCKLYN | |
| SCHEMBL9984228 | 0.77 | BTK (0.45) | BTKJAK2ROCK2 | |
| SCHEMBL124441 | 0.76 | BTK (0.67) | BTKJAK2AURKALCKLYN | |
| SCHEMBL12071962 | 0.75 | JAK2 (0.49) | BTKJAK2 | |
| SCHEMBL9983389 | 0.74 | BTK (0.49) | BTKJAK2AURKALCKLYN | |
| SCHEMBL9984203 | 0.74 | PRKAB2 (0.35) | BTKJAK2AURKALCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011159857-A1 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-22 | — | — | WO | disclosed |