Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 14/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | GLP1R | P43220 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.61 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.61 |
| ▸ | PNLIP | P16233 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12076275 | 0.94 | AVPR2 (0.60) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL533754 | 0.91 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL30354671 | 0.91 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL31344362 | 0.91 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL14962830 | 0.88 | AVPR2 (0.67) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| Tolvaptan SCHEMBL12076193 | 0.83 | AVPR2 (0.84) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL14962832 | 0.83 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| Tolvaptan SCHEMBL12076380 | 0.82 | AVPR2 (0.69) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL26405946 | 0.82 | AVPR2 (0.68) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL20407284 | 0.80 | AVPR2 (0.71) | AVPR2AVPR1AABCB11ADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940727-B2 | Benzazepine compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-01-27 | — | — | US | disclosed |
| US-20130131045-A1 | BENZAZEPINE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-05-23 | — | — | US | disclosed |
| US-20130131045-A1 | BENZAZEPINE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-05-23 | — | — | US | disclosed |
| EP-2495236-A1 | BENZAZEPINE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2012-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131045-A1 | BENZAZEPINE COMPOUND | AVPR2, AVPR1B, AVPR1A | AVPR2 1/4885AVPR1A 3/4885ABCB11 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.