Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 13/20 | 0.70 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | HRH1 | P35367 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | GLP1R | P43220 | 1/20 | 0.70 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.70 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.70 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | OXTR | P30559 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354671 | 1.00 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL31344362 | 1.00 | AVPR2 (0.70) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL14962830 | 0.92 | AVPR2 (0.67) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL12076284 | 0.91 | AVPR2 (0.61) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL26405946 | 0.91 | AVPR2 (0.68) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL20407284 | 0.87 | AVPR2 (0.71) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL12076275 | 0.86 | AVPR2 (0.60) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL7351642 | 0.86 | AVPR2 (0.57) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL28625477 | 0.85 | AVPR2 (0.51) | AVPR2AVPR1AABCB11ADRB2HTR1A | |
| SCHEMBL26405907 | 0.84 | AVPR2 (0.60) | AVPR2AVPR1AABCB11ADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117756717-A | Tolvaptan intermediate and preparation method of tollvaptan | 广州市桐晖药业有限公司 | 2024-03-26 | — | — | CN | claimed |
| US-9428461-B2 | Process for the preparation of a benzazepine derivative | RPG LIFE SCIENCES LIMITED (IN) | 2016-08-30 | — | — | US | claimed |
| US-9024015-B2 | Process for preparing tolvaptan intermediates | HETERO RESEARCH FOUNDATION (IN) | 2015-05-05 | — | — | US | claimed |
| US-20150112059-A1 | PROCESS FOR THE PREPARATION OF A BENZAZEPINE DERIVATIVE | RPG LIFE SCIENCES LIMITED (IN) | 2015-04-23 | — | — | US | claimed |
| EP-2261215-B1 | Process for preparing benzazepine compounds or salts thereof | OTSUKA PHARMA CO LTD (JP) | 2014-12-31 | — | — | EP | claimed |
| EP-2624693-A1 | PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES | Hetero Research Foundation (IN) | 2013-08-14 | — | — | EP | claimed |
| US-20130190490-A1 | PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES | HETERO RESEARCH FOUNDATION (IN) | 2013-07-25 | — | — | US | claimed |
| US-8273735-B2 | Process for preparing benzazepine compounds or salts thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-09-25 | — | — | US | claimed |
| WO-2012046244-A1 | PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES | HETERO RESEARCH FOUNDATION (IN) | 2012-04-12 | — | — | WO | claimed |
| EP-2261215-A1 | Process for preparing benzazepine compounds or salts thereof | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-12-15 | — | — | EP | claimed |
| US-20090306369-A1 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | claimed |
| EP-1919874-A2 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF | Otsuka Pharmaceutical Company, Limited (JP) | 2008-05-14 | — | — | EP | claimed |
| WO-2007026971-A2 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | claimed |
| CN-117756717-A | Tolvaptan intermediate and preparation method of tollvaptan | 广州市桐晖药业有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20240076279-A1 | NOVEL BENZOAZEPINE COMPOUND, AND COMPOSITION AND USE THEREOF | XUZHOU MEDICAL UNIVERSITY (CN) | 2024-03-07 | — | — | US | disclosed |
| WO-2022156449-A1 | NOVEL BENZOAZEPINE COMPOUND, AND COMPOSITION AND USE THEREOF | 徐州医科大学 | 2022-07-28 | — | — | WO | disclosed |
| US-5622947-A | VASODILATORS, HYPOTENSIVE AGENTS, DIURETICS, PLATELET AGGLUTINATION INHIBITORS; ALSO USED TO PREVENT PREMATURE BIRTH, TREAT DYSMENORRHEA | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-22 | — | — | US | disclosed |
| EP-0514667-B1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMA CO LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0620003-A1 | VASOPRESSIN ANTAGONIST AND OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| EP-0514667-A1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306369-A1 | PROCESS FOR PREPARING BENZAZEPINE COMPOUNDS OR SALTS THEREOF | AVPR2, AVPR1B, AVPR1A | AVPR2 1/4885AVPR1A 3/4885ABCB11 746/4885 |
| US-20240076279-A1 | NOVEL BENZOAZEPINE COMPOUND, AND COMPOSITION AND USE THEREOF | AVPR1B, AVPR2, AVPR1A | AVPR2 2/4885AVPR1A 3/4885ABCB11 956/4885 |
| US-20150112059-A1 | PROCESS FOR THE PREPARATION OF A BENZAZEPINE DERIVATIVE | HTR5A, HTR4, HTR2C | AVPR2 159/4885AVPR1A 196/4885ABCB11 955/4885 |
| US-20130190490-A1 | PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES | HTR5A, TPH1, HTR4 | AVPR2 137/4885AVPR1A 171/4885ABCB11 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.