Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ACVR1B | P36896 | 9/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.43 |
| ▸ | ACP1 | P24666 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090374 | 0.87 | TGFBR1 (0.45) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090419 | 0.85 | TGFBR1 (0.65) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12090687 | 0.82 | TGFBR1 (0.47) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090543 | 0.82 | TGFBR1 (0.47) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090730 | 0.82 | TGFBR1 (0.59) | TGFBR1CYP3A4HTTACVR1BACVRL1 | |
| SCHEMBL12090595 | 0.81 | TGFBR1 (0.47) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090701 | 0.80 | TGFBR1 (0.46) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090773 | 0.80 | ACP1 (0.49) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090615 | 0.78 | ACP1 (0.47) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 | |
| SCHEMBL12090624 | 0.78 | TGFBR1 (0.48) | TGFBR1CYP3A4ACVR1BACVRL1ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987301-B2 | Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-8987301-B2 | Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-20120225875-A1 | HETEROARYLAMINOQUINOLINES AS TGF-BETA RECEPTOR KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-09-06 | — | — | US | disclosed |
| US-20120225875-A1 | HETEROARYLAMINOQUINOLINES AS TGF-BETA RECEPTOR KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225875-A1 | HETEROARYLAMINOQUINOLINES AS TGF-BETA RECEPTOR KINASE INHIBITORS | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885CYP3A4 2031/4885HTT 2868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.