Known targets — ChEMBL curated mechanism
HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7
The experimentally established mechanism targets of Dexfenfluramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 4/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.62 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.56 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.45 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.45 |
| ▸ | HTR5A known ✓ | P47898 | 1/20 | 0.45 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.97 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.97 |
| ▸ | DRD3 | P35462 | 4/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenfluramine SCHEMBL11140094 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Levofenfluramine SCHEMBL30951308 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Dexfenfluramine SCHEMBL29362838 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL6276588 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL39491 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL9080932 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL9276141 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL10947502 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL10602733 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL20590765 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6342 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120138634-A | Environment-friendly efficient polishing and freckle-developing process for brass artware | 广州番禺职业技术学院 | 2025-06-13 | — | — | CN | claimed |
| CN-118924651-B | Composition with anti-dandruff effect and preparation method thereof | 珑玥实业(广州)有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119059878-A | High-carbon isomeric alcohol for preparing aviation fuel and preparation method thereof | 广东工业大学 | 2024-12-03 | — | — | CN | claimed |
| CN-119028481-A | Method for constructing vector prediction model of dissolved organic matter isomeride based on graph learning | 香港科技大学深圳研究院 | 2024-11-26 | — | — | CN | claimed |
| CN-118930404-A | Method for optimizing butanol and octanol product structure | 天津渤化永利化工股份有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-118831531-A | Method and system for producing paraxylene by using low-carbon aromatic hydrocarbon | 中国石化工程建设有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-118813219-A | Temperature-resistant salt-resistant anti-swelling clay stabilizer and preparation process and application thereof | 北京弘毅恩泽能源技术有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-115772067-B | Purification method of high-reflection-type special hydrogenated bisphenol A | 本源精化环保科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118459369-A | Synthetic method of N-Boc-vinyl glycine methyl ester and isomer thereof | 成都师范学院 | 2024-08-09 | — | — | CN | claimed |
| CN-118398109-A | Physical property data prediction method and device for flow simulation | 广东辛孚科技有限公司 | 2024-07-26 | — | — | CN | claimed |
| EP-0924521-A1 | Competitive apo-peroxidase assay | Bayer Corporation (US) | 1999-06-23 | — | — | EP | claimed |
| CN-1210856-A | Process for preparation of heteroarylcarboxamides | AMERICAN CYANAMID CO (US) | 1999-03-17 | — | — | CN | claimed |
| CN-1041513-C | Inhibiting polymerization of vinyl aromatic monomers | CIBA GEIGY AG (CH) | 1999-01-06 | — | — | CN | claimed |
| EP-0882700-A2 | Process for the production of the dexfenfluramine hydrochloride | ALFA CHEMICALS ITALIANA S.p.A. (IT) | 1998-12-09 | — | — | EP | claimed |
| CN-1185209-A | Assaying protein fragments in body fluids | OSTEOMETER BIOTECH AS (DK) | 1998-06-17 | — | — | CN | claimed |
| CN-1166820-A | Method for inhibiting premature polymerization of aromatic vinyl monomers | CIBA GEIGY AG (CH) | 1997-12-03 | — | — | CN | claimed |
| CN-1163312-A | Novel sphingomyelin and its preparing method | ROHM & HAAS (US) | 1997-10-29 | — | — | CN | claimed |
| CN-1121202-A | Chinese character input method for computer | LIU LIANXUN (CN) | 1996-04-24 | — | — | CN | claimed |
| CN-1084155-A | The resistance of vi-ny l aromatic monomers is poly- | CIBA GEIGY AG (US) | 1994-03-23 | — | — | CN | claimed |
| CN-1053859-A | Reclaim the method for the plutonium (IV) in solution such as waste water, fission product strong solution and the concentrated solution of plutonium with crown compound | COGEMA COMPAGNIC GENERALE DES (FR) | 1991-08-14 | — | — | CN | claimed |