Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenfluramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.94 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.60 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.94 |
| ▸ | HTR2A | P28223 | 4/20 | 0.94 |
| ▸ | HTR2B | P41595 | 4/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.94 |
| ▸ | DRD3 | P35462 | 4/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenfluramine SCHEMBL9080932 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL9276141 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL39491 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL11140094 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Dexfenfluramine SCHEMBL120916 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL6276588 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Dexfenfluramine SCHEMBL29362838 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Levofenfluramine SCHEMBL30951308 | 0.98 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL7158773 | 0.97 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL10602733 | 0.97 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642375-B1 | IMPROVED THICK WROUGHT 7XXX ALUMINUM ALLOYS, AND METHODS FOR MAKING THE SAME | ARCONIC TECH LLC (US) | 2022-01-05 | — | — | EP | claimed |
| EP-3400317-B1 | HOT-DIP GALVANIZATION SYSTEM AND HOT-DIP GALVANIZATION METHOD FOR MASS PRODUCTION | FONTAINE HOLDINGS NV (BE) | 2019-10-02 | — | — | EP | claimed |
| EP-1390564-B1 | METHOD FOR COATING METALLIC SURFACES AND USE OF THE SUBSTRATES COATED IN THIS MANNER | CHEMETALL GMBH (DE) | 2009-02-11 | — | — | EP | claimed |
| EP-0315059-B1 | PROCESS AND COMPOSITION FOR ZINC PHOSPHATE COATING | HENKEL CORPORATION (a Delaware corp.) (US) | 1993-03-10 | — | — | EP | claimed |
| EP-0215041-B1 | PROCESS FOR THE PHOSPHATING OF METAL SURFACES | Henkel Kommanditgesellschaft auf Aktien (DE) | 1988-08-17 | — | — | EP | disclosed |
| WO-1986004931-A1 | PROCESS FOR THE PHOSPHATING OF METAL SURFACES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1986-08-28 | — | — | WO | disclosed |