Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenfluramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.62 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.97 |
| ▸ | HTR2A | P28223 | 4/20 | 0.97 |
| ▸ | HTR2B | P41595 | 4/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.97 |
| ▸ | DRD3 | P35462 | 4/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenfluramine SCHEMBL11140094 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Levofenfluramine SCHEMBL30951308 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Dexfenfluramine SCHEMBL29362838 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL6276588 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL9080932 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL9276141 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Dexfenfluramine SCHEMBL120916 | 1.00 | SLC6A4 (0.97) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL10947502 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL10602733 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C | |
| Fenfluramine SCHEMBL20590765 | 0.98 | SLC6A4 (0.94) | SLC6A4SIGMAR1HTR2AHTR2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 38333 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250213547-A1 | METHODS OF TREATING NEUROLOGICAL DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2025-07-03 | — | — | US | claimed |
| EP-4293009-B1 | FENFLURAMINE COMPOSITIONS AND METHODS OF PREPARING THE SAME | ZOGENIX INTERNATIONAL LTD (GB) | 2025-06-11 | — | — | EP | claimed |
| CN-119790152-A | Treatment of neurological disorders using modulators of UNC13A gene transcripts | 奎里斯公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119522282-A | Splice transducer antisense oligonucleotides with modified backbone chemistry | 奎里斯公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119452086-A | GAPMER antisense oligonucleotides with modified backbone chemistry | 奎里斯公司 | 2025-02-14 | — | — | CN | claimed |
| US-20250051766-A1 | TREATMENT OF NEUROLOGICAL DISEASES USING MODULATORS OF UNC13A GENE TRANSCRIPTS | QURALIS CORPORATION | 2025-02-13 | — | — | US | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-3800177-B1 | FENFLURAMINE COMPOSITIONS AND METHODS OF PREPARING THE SAME | ZOGENIX INTERNATIONAL LTD (GB) | 2025-01-29 | — | — | EP | claimed |
| WO-2023102242-A9 | SPLICE SWITCHER ANTISENSE OLIGONUCLEOTIDES WITH MODIFIED BACKBONE CHEMISTRIES | QURALIS CORPORATION (US) | 2024-10-31 | — | — | WO | claimed |
| US-20240343675-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- A -METHYL-3-(TRIFLUOROMETHYL) PHENETHYLAMINE HYDROCHLORIDE | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2024-10-17 | — | — | US | claimed |
| US-4187119-A | Glue for articles in the tobacco industry | SERVICE D'EXPLOITATION INDUSTRIELLE DES TABACS ET DES ALLUMETTES (FR) | 1980-02-05 | — | — | US | claimed |
| EP-0006390-A1 | Process of forming a fibrous web by the papermaking technique in order to improve the binding and retention, web obtained by this process and its use as a substitute material for asbestos products and as a printing or writing support | ARJOMARI-PRIOUX S.A. (FR) | 1980-01-09 | — | — | EP | claimed |
| US-4178465-A | Processes for preparing perfluoropolyether oils of very high purity and low volatility | MONTEDISON S.P.A. (IT) | 1979-12-11 | — | — | US | claimed |
| EP-0004407-A2 | Process for the production of peracids and their use for the preparation of epoxides from olefins | PROPYLOX (Société Anonyme) (BE) | 1979-10-03 | — | — | EP | claimed |
| EP-0004237-A1 | Ion exchange membranes; their preparation and their use in the electrolysis of sodium chloride | ELF ATOCHEM S.A. (FR) | 1979-09-19 | — | — | EP | claimed |
| EP-0003932-A1 | Saturated cross-linkable polyester compositions for a powder coating with a mat and/or glossy surface and process for preparing such a coating | CdF CHIMIE RESINES (FR) | 1979-09-05 | — | — | EP | claimed |
| EP-0003704-A1 | Method of and apparatus for continuously mixing powdery solids and liquids, especially plaster with water | SAINT-GOBAIN INDUSTRIES (FR) | 1979-08-22 | — | — | EP | claimed |
| EP-0001859-A1 | Rigid compositions based on polyvinyl chloride, heat stabilised with a mixture of magnesium oxide and a polyol | SOLVAY & Cie (Société Anonyme) (BE) | 1979-05-16 | — | — | EP | claimed |
| EP-0001196-A1 | Device for the automatic control of a filling apparatus for receptacles | S.E.R.A.C. GROUP (FR) | 1979-03-21 | — | — | EP | claimed |
| EP-0001190-A1 | Use of carboxymethylgalactomannangels as carriers in products for air-treatment | C E C A S.A. (FR) | 1979-03-21 | — | — | EP | claimed |