SCHEMBL12092629

SCHEMBL12092629

CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@@H](C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 13/20 0.52
▸ MC1R Q01726 8/20 0.52
▸ FURIN P09958 1/20 0.49
▸ MC5R P33032 3/20 0.48
▸ MC3R P41968 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20206361 1.00 MC4R (0.52) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092650 0.94 MC4R (0.47) MC4RMC1RFURINMC5RMC3R
SCHEMBL21392481 0.94 MC4R (0.47) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092735 0.94 MC4R (0.47) MC4RMC1RFURINMC5RMC3R
SCHEMBL20362997 0.94 MC4R (0.47) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092579 0.94 MC4R (0.47) MC4RMC1RFURINMC5RMC3R
SCHEMBL21392454 0.93 MC4R (0.52) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092736 0.93 MC4R (0.48) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092526 0.93 MC4R (0.48) MC4RMC1RFURINMC5RMC3R
SCHEMBL12092575 0.92 MC4R (0.47) MC4RMC1RMC5RMC3R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy PALATIN TECHNOLOGIES, INC. (US) 2022-03-29 — — US disclosed
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy PALATIN TECHNOLOGIES INC (US) 2020-10-29 — — US disclosed
WO-2019183472-A1 MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDE FORMULATIONS AND METHODS FOR GASTROINTESTINAL TRACT-SPECIFIC DELIVERY PALATIN TECHNOLOGIES, INC. (US) 2019-09-26 — — WO disclosed
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides PALATIN TECHNOLOGIES, INC. (US) 2018-07-10 — — US disclosed
US-20170008931-A1 Melanocortin-1 Receptor-Specific Cyclic Hexapeptides PALATIN TECHNOLOGIES INC (US) 2017-01-12 — — US disclosed
US-9447148-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2016-09-20 — — US disclosed
US-20150038434-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides PALATIN TECHNOLOGIES INC (US) 2015-02-05 — — US disclosed
US-8877890-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2014-11-04 — — US disclosed
US-20130296256-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides PALATIN TECHNOLOGIES, INC. (US) 2013-11-07 — — US disclosed
US-8492517-B2 Melanocortin-1 receptor-specific cyclic peptides PALATIN TECHNOLOGIES, INC. (US) 2013-07-23 — — US disclosed
US-20120225828-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides PALATIN TECHNOLOGIES, INC. (US) 2012-09-06 — — US disclosed
WO-2011063366-A1 MELANOCORTIN-1 RECEPTOR-SPECIFIC CYCLIC PEPTIDES PALATIN TECHNOLOGIES, INC. (US) 2011-05-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy MC3R, MC1R, MC2R MC4R 6/4885MC1R 2/4885FURIN 400/4885
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 867/4885
US-20120225828-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 1147/4885
US-20150038434-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 1147/4885
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy MC3R, MC1R, MC2R MC4R 6/4885MC1R 2/4885FURIN 400/4885
US-20170008931-A1 Melanocortin-1 Receptor-Specific Cyclic Hexapeptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 867/4885
US-20130296256-A1 Melanocortin-1 Receptor-Specific Cyclic Peptides MC1R, MC3R, MC5R MC4R 4/4885MC1R 1/4885FURIN 1147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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