Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 16/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12345378 | 0.88 | OPRK1 (0.52) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL12094701 | 0.86 | OPRK1 (0.55) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL20989498 | 0.84 | GPR119 (0.51) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL12345386 | 0.84 | GPR119 (0.51) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL2979574 | 0.83 | GPR119 (0.54) | GPR119 | |
| SCHEMBL30829543 | 0.83 | USP30 (0.46) | CHRM1GPR119 | |
| SCHEMBL27369785 | 0.83 | USP30 (0.46) | CHRM1GPR119 | |
| SCHEMBL12094664 | 0.83 | OPRK1 (0.50) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL12094631 | 0.82 | OPRK1 (0.54) | OPRK1KCNH2OPRM1OPRD1CHRM1 | |
| SCHEMBL12094723 | 0.82 | GPR119 (0.43) | CHRM1GPR119CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933229-B2 | 8-azabicyclo[3.2.1]octane-8-carboxamide derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-01-13 | — | — | US | disclosed |
| EP-2500345-A1 | 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-09-19 | — | — | EP | disclosed |
| US-20120225876-A1 | 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-09-06 | — | — | US | disclosed |
| WO-2011059021-A1 | 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225876-A1 | 8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE | HDAC10, HDAC11, HDAC1 | OPRK1 495/4885KCNH2 336/4885OPRM1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.