SCHEMBL12100899

SCHEMBL12100899

Cc1cccc(Nc2nccc(C)c2N)c1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 8/20 0.51
ERBB2 P04626 1/20 0.51
KMT2A Q03164 1/20 0.51
ABL1 P00519 1/20 0.48
ABL2 P42684 1/20 0.48
GRM4 Q14833 1/20 0.48
NPSR1 Q6W5P4 1/20 0.47
HTT P42858 2/20 0.47
HIF1A Q16665 1/20 0.47
AURKA O14965 1/20 0.47
MAPK1 P28482 2/20 0.45
TSHR P16473 1/20 0.45
RAB9A P51151 1/20 0.45
GFER P55789 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HSD17B10 Q99714 1/20 0.45
RAPGEF4 Q8WZA2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7443977 0.83 NOS3 (0.47) EGFRKMT2AABL1ABL2HTT
Hydrochloric Acid SCHEMBL11127891 0.82 NOS3 (0.46) EGFRKMT2AABL1ABL2HTT
SCHEMBL17503366 0.81 NPSR1 (0.59) EGFRERBB2KMT2AABL1ABL2
Hydrochloric Acid SCHEMBL17503358 0.80 HTT (0.58) EGFRERBB2KMT2AABL1ABL2
SCHEMBL30269613 0.79 GRM4 (0.56) EGFRERBB2KMT2AABL1ABL2
SCHEMBL6798480 0.79 GRM4 (0.56) EGFRERBB2KMT2AABL1ABL2
SCHEMBL16381740 0.78 PIK3CA (0.47) EGFRABL1
SCHEMBL15179513 0.78 EGFR (0.55) EGFRERBB2KMT2AHTTHIF1A
SCHEMBL28212946 0.76 TNNI3K (0.54) EGFRERBB2KMT2AABL1ABL2
SCHEMBL12172471 0.76 EGFR (0.54) EGFRERBB2KMT2AABL1ABL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11600791-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-03-07 US disclosed
EP-3936512-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2022-01-12 EP disclosed
EP-3424935-B1 IMIDAZOPYRAZINYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORP (US) 2021-08-11 EP disclosed
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-02-18 US disclosed
US-10873038-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-12-22 US disclosed
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-04-11 US disclosed
EP-3424935-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2019-01-09 EP disclosed
EP-2683728-B1 IRIDIUM COMPLEXES WITH 3-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE, 3-PHENYL-3H-IMIDAZO[4,5-b]PYRAZINE AND 1-PHENYL-3H-IMIDAZO[4,5-b]PYRIDINE CARBENE LIGANDS USED AS PHOSPHORESCENT EMITTERS IN ORGANIC LIGHT EMITTING DEVICES UNIVERSAL DISPLAY CORP (US) 2018-09-05 EP disclosed
US-9972793-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2018-05-15 US disclosed
US-20150021590-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-01-22 US disclosed
US-8883322-B2 Pyridyl carbene phosphorescent emitters UNIVERSAL DISPLAY CORPORATION (US) 2014-11-11 US disclosed
EP-2683728-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS Universal Display Corporation (US) 2014-01-15 EP disclosed
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 US disclosed
WO-2012121936-A2 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS UNIVERSAL DISPLAY CORPORATION (US) 2012-09-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210050530-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 EGFR 3203/4885ERBB2 3033/4885KMT2A 3120/4885
US-10873038-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 EGFR 3203/4885ERBB2 3033/4885KMT2A 3120/4885
US-20120228583-A1 PYRIDYL CARBENE PHOSPHORESCENT EMITTERS PAICS, PIR, NUDC EGFR 3411/4885ERBB2 2109/4885KMT2A 3226/4885
US-20190109287-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NUDC, NCL, NDC1 EGFR 3203/4885ERBB2 3033/4885KMT2A 3120/4885
US-11600791-B2 Organic electroluminescent materials and devices NUDC, NCL, NDC1 EGFR 3203/4885ERBB2 3033/4885KMT2A 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.