Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141841 | 0.83 | CHRM2 (0.64) | CHRM2CHRM3 | |
| SCHEMBL12095659 | 0.81 | CHRM2 (0.58) | CHRM2CHRM3CYP3A4CYP2D6USP2 | |
| SCHEMBL12101048 | 0.74 | CYP3A4 (0.49) | CYP3A4CYP2D6USP2HSD17B10TSHR | |
| SCHEMBL2142020 | 0.72 | CHRM2 (0.67) | CHRM2CHRM3 | |
| SCHEMBL12101073 | 0.70 | CHRM2 (0.45) | CHRM2CHRM3CYP3A4CYP2D6USP2 | |
| SCHEMBL29944255 | 0.68 | NPC1 (0.57) | HSD17B10TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL12101040 | 0.67 | GRM5 (0.43) | CYP3A4CYP2D6USP2TSHRCYP2C19 | |
| SCHEMBL12101012 | 0.65 | CHRM2 (0.56) | CHRM2CHRM3CYP3A4CYP2D6USP2 | |
| SCHEMBL2142054 | 0.65 | CHRM2 (0.63) | CHRM2CHRM3 | |
| SCHEMBL19107352 | 0.65 | CHRM2 (0.61) | CHRM2CHRM3ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |