Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 13/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10242601 | 0.78 | ADRB2 (0.52) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| SCHEMBL12101076 | 0.78 | ADRB2 (0.47) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| Formic Acid SCHEMBL2142847 | 0.77 | ADRB2 (0.51) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| Formic Acid SCHEMBL2142822 | 0.77 | ADRB2 (0.51) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| SCHEMBL12101048 | 0.76 | CYP3A4 (0.49) | USP2CYP3A4CYP2D6TSHR | |
| SCHEMBL12100968 | 0.74 | ADRB2 (0.55) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| SCHEMBL2139288 | 0.74 | CHRM3 (0.44) | ADRB2ADRB1CHRM3DRD3 | |
| SCHEMBL2142827 | 0.73 | ADRB2 (0.44) | ADRB2ADRB1DRD2CHRM3 | |
| SCHEMBL12100965 | 0.72 | ADRB2 (0.47) | ADRB2ADRB1DRD2ADRA1DCHRM3 | |
| SCHEMBL2140483 | 0.72 | CHRM3 (0.42) | ADRB2ADRB1DRD2ADRA1DCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |