Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 6/20 | 0.43 |
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825012 | 0.88 | ATM (0.55) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL1186455 | 0.88 | ATM (0.55) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL825959 | 0.88 | ATM (0.55) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL3697318 | 0.87 | CTSS (0.56) | MEN1GAAKMT2AAAK1SYK | |
| SCHEMBL2799041 | 0.87 | GAA (0.50) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL2799300 | 0.87 | GAA (0.50) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL16798329 | 0.87 | CTSS (0.56) | MEN1GAAKMT2ASYKATM | |
| SCHEMBL16798417 | 0.86 | LDHA (0.52) | MEN1GAAKMT2ASYKITGB3 | |
| SCHEMBL16800247 | 0.85 | SYK (0.43) | GAAAAK1SYKATMCTSS | |
| SCHEMBL30718545 | 0.84 | CYP17A1 (0.47) | MEN1GAAKMT2ASYKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242755-B1 | PYRROLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-09-12 | — | — | EP | disclosed |