Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.66 |
| ▸ | PGR | P06401 | 8/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | IL5 | P05113 | 1/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | MMP9 | P14780 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12103778 | 0.91 | NR3C1 (0.66) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL21569934 | 0.90 | NR3C1 (0.72) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL21153569 | 0.89 | NR3C1 (0.69) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL4445957 | 0.88 | NR3C1 (0.75) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL21152871 | 0.88 | NR3C1 (0.74) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL21152601 | 0.88 | NR3C1 (0.74) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL13816838 | 0.87 | NR3C1 (0.73) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL4452247 | 0.87 | NR3C1 (0.73) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL12103378 | 0.86 | NR3C1 (0.47) | NR3C1PGRCYP3A4HIF1AABCC3 | |
| SCHEMBL13491175 | 0.86 | NR3C1 (0.65) | NR3C1PGRCYP3A4HIF1AABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357723-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-22 | — | — | US | disclosed |
| US-8357723-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-22 | — | — | US | disclosed |
| US-8354455-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-15 | — | — | US | disclosed |
| US-8354455-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-15 | — | — | US | disclosed |
| US-8349901-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-08 | — | — | US | disclosed |
| US-8349901-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-08 | — | — | US | disclosed |
| US-20110274695-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | PIRAMAL LIFE SCIENCES LIMITED | 2011-11-10 | — | — | US | disclosed |
| US-20110274695-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | PIRAMAL LIFE SCIENCES LIMITED | 2011-11-10 | — | — | US | disclosed |
| US-20110269709-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | PIRAMAL LIFE SCIENCES LIMITED | 2011-11-03 | — | — | US | disclosed |
| US-20110269709-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | PIRAMAL LIFE SCIENCES LIMITED | 2011-11-03 | — | — | US | disclosed |
| US-20110269722-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | Piramal Life Science Limited | 2011-11-03 | — | — | US | disclosed |
| US-20110269722-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | Piramal Life Science Limited | 2011-11-03 | — | — | US | disclosed |
| US-7932294-B2 | Prodrugs containing novel bio-cleavable linkers | APPARAO SATYAM (IN) | 2011-04-26 | — | — | US | disclosed |
| US-7932294-B2 | Prodrugs containing novel bio-cleavable linkers | APPARAO SATYAM (IN) | 2011-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269722-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | SI, UGT1A1, CYP2B6 | NR3C1 4365/4885PGR 1386/4885CYP3A4 21/4885 |
| US-20110274695-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | SI, UGT1A1, CYP2B6 | NR3C1 4365/4885PGR 1386/4885CYP3A4 21/4885 |
| US-20110269709-A1 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS | SI, UGT1A1, CYP2B6 | NR3C1 4365/4885PGR 1386/4885CYP3A4 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.