Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.77 |
| ▸ | CYBB | P04839 | 6/20 | 0.74 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NOX5 | Q96PH1 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303531 | 0.90 | NOX4 (0.65) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL29522756 | 0.90 | NOX4 (0.75) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL14931743 | 0.90 | NOX4 (0.75) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL1302409 | 0.89 | NOX4 (0.72) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL1303502 | 0.88 | NOX4 (0.68) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL1303321 | 0.87 | NOX4 (1.00) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL1302610 | 0.86 | NOX4 (0.81) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL16622932 | 0.86 | NOX4 (0.68) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL3614947 | 0.85 | NOX4 (0.84) | NOX4CYBBNOX1CYP3A4 | |
| SCHEMBL1723441 | 0.85 | NOX4 (1.00) | NOX4CYBBNOX1CYP3A4NOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269757-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-11-03 | — | — | US | disclosed |
| WO-2010035221-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269757-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | NOX1, NOX4, CYBB | NOX4 2/4885CYBB 3/4885NOX1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.