Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.68 |
| ▸ | CYBB | P04839 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.67 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29522767 | 0.87 | NOX4 (0.66) | NOX4CYBBCYP3A4NOX1CYP2C8 | |
| SCHEMBL14931767 | 0.87 | NOX4 (0.66) | NOX4CYBBCYP3A4NOX1CYP2C8 | |
| SCHEMBL12107202 | 0.86 | NOX4 (0.77) | NOX4CYBBCYP3A4NOX1CYP2C8 | |
| SCHEMBL14931743 | 0.85 | NOX4 (0.75) | NOX4CYBBCYP3A4NOX1CYP2C8 | |
| SCHEMBL29522756 | 0.85 | NOX4 (0.75) | NOX4CYBBCYP3A4NOX1CYP2C8 | |
| SCHEMBL1302409 | 0.82 | NOX4 (0.72) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1723441 | 0.81 | NOX4 (1.00) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL30637790 | 0.81 | NOX4 (1.00) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1303321 | 0.80 | NOX4 (1.00) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1303296 | 0.80 | NOX4 (0.71) | NOX4CYBBCYP3A4NOX1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857399-A1 | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction | GenKyoTex SA (CH) | 2015-04-08 | — | — | EP | disclosed |