Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.48 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPA | Q15257 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13771684 | 1.00 | METTL3 (0.48) | METTL3CTSAFABP3FABP4FABP5 | |
| SCHEMBL12108363 | 0.93 | METTL3 (0.48) | METTL3PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12108361 | 0.90 | METTL3 (0.46) | METTL3CTSAPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL12108366 | 0.86 | METTL3 (0.59) | METTL3CTSAPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL12108378 | 0.85 | METTL3 (0.43) | METTL3PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL1301310 | 0.85 | METTL3 (0.46) | METTL3 | |
| SCHEMBL1301309 | 0.85 | METTL3 (0.46) | METTL3 | |
| SCHEMBL12108370 | 0.84 | METTL3 (0.44) | METTL3PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12108382 | 0.84 | METTL3 (0.41) | METTL3PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL12110682 | 0.84 | PIK3CA (0.42) | METTL3PRKAG1PRKAA1PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | AARDEA BIOSCIENCES, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | AARDEA BIOSCIENCES, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | METTL3 2709/4885CTSA 1665/4885FABP3 4132/4885 |
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | METTL3 2709/4885CTSA 1665/4885FABP3 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.